Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice.
Domiziana CostamagnaRobin DuelenFabio PennaDetlef NeumannPaola CostelliMaurilio SampaolesiPublished in: Journal of cachexia, sarcopenia and muscle (2020)
The results here presented shed new light on IL4 signalling during muscle wasting and early stages of muscle regeneration that explain the beneficial effect observed in IL4-treated C26 mice. These findings might aid to develop therapeutic approaches to improve mobility and quality of life in cachectic patients.