Pharmacokinetics of Ginkgolide B Lyophilized Nanoparticles Following Intravenous Injection in Rats by Using LC-MS/MS.

Lisha MaLujia ZhuJianan PengShujun XuYue ZhaoJingbin ShiQi LiuHui ZhangJun LiYang Xiong

Published in: Rapid communications in mass spectrometry : RCM (2022)

A rapid and accurate LC-MS/MS method was established for the determination of GB-NPs in rats. GB-NPs exhibited a sustained-release behavior in vivo comparing with GB solution.

Keyphrases

high dose
high resolution
solid phase extraction
mass spectrometry
loop mediated isothermal amplification