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Photothermal-Responsive Intelligent Hybrid of Hierarchical Carbon Nanocages Encapsulated by Metal-Organic Hydrogels for Sensitized Photothermal Therapy.

Fang WangBaoxing WangXiang XuXiaoliang WangPei JiangZheng HuXizhang WangJianping Lei
Published in: Advanced healthcare materials (2023)
Hierarchical carbon nanocages as emerging nanomaterials have a great potential for photothermal therapy due to their unique porous structure, high specific surface area and excellent photothermal property. Herein, we introduce a hierarchical nitrogen-doped carbon nanocage (hNCNC) as a second near-infrared photothermal agent, and then functionalizes it with metal-organic hydrogel (MOG) to form a thermal-responsive switch for sensitized photothermal therapy. Upon 1064 nm light irradiation, the hNCNCs exhibit a remarkable photothermal conversion efficiency of 65.9% owing to a high near-infrared extinction coefficient. Meanwhile, due to the hierarchical structure, hNCNCs show 60.2% (wt/wt) loading efficiency of quercetin, a heat shock protein (Hsp70) inhibitor. Through thermal-driven dry-gel transformation, the coating MOGs intelligently release the encapsulated quercetin for sensitizing cancer cells to heat. Based on the synergistic effect of hyperthermia elevation and thermal-driven drug release, the dual thermal utilization platform achieves effective photothermal tumor ablation in vivo under low concentration of hNCNCs and mild irradiation, which provides a new diagram of intelligent responsive photothermal agents for enhanced photothermal therapy. This article is protected by copyright. All rights reserved.
Keyphrases
  • drug release
  • cancer therapy
  • drug delivery
  • photodynamic therapy
  • heat shock protein
  • heat stress
  • hyaluronic acid
  • heat shock
  • oxidative stress
  • magnetic resonance
  • radiation induced
  • light emitting