ZFHX3 knockdown dysregulates mitochondrial adaptations to tachypacing in atrial myocytes through enhanced oxidative stress and calcium overload.
Baigalmaa LkhagvaYung-Kuo LinYao-Chang ChenWan-Li ChengSatoshi HigaYu-Hsun KaoYi-Jen ChenPublished in: Acta physiologica (Oxford, England) (2020)
ZFHX3 KD cells modulate mitochondrial adaptations to tachypacing in HL-1 cardiomyocytes through Ca2+ overload, oxidative stress and metabolic disorder. Targeting IP3 R signalling or oxidative stress could reduce AF.