Biological basis of extensive pleiotropy between blood traits and cancer risk.
Miguel Angel Pardo-CeaXavier FarréAnna EsteveJoanna PaladeRoderic EspínFrancesca MateoEric AlsopMarc AlordaNatalia BlayAlexandra BaigesArzoo ShabbirFrancesc ComellasAntonio GómezMontserrat ArnanAlex TeuléMonica SalinasLaura BerrocalJoan BrunetPaula RofesConxi LázaroMiquel ConesaJuan Jose RojasLars VeltenWojciech FendlerUrszula SmyczynskaDipanjan ChowdhuryYong ZengHousheng Hansen HeRong LiKendall Van Keuren-JensenRafael de CidMiguel Angel PujanaPublished in: Genome medicine (2024)
This study reveals extensive pleiotropism between blood traits and cancer risk. Pleiotropism is linked to factors and processes involved in hematopoietic development and immune system function, including components of the major histocompatibility complexes, and regulators of telomere length and myeloid lineage. Deregulation of Y-RNAs is also associated with pleiotropism. Overexpression of these elements might indicate increased cancer risk.