Intramyocardial Sprouting Tip Cells Specify Coronary Arterialization.
Elena CanoJennifer SchwarzkopfMasatoshi KandaEric Lars-Helge LindbergIrene HollfingerCristina PogontkeCaroline BraeuningCornelius FischerNorbert HübnerHolger GerhardtPublished in: Circulation research (2024)
A tip cell-to-artery specification mechanism drives arterialization of the intramyocardial plexus and endocardial tunnels throughout life and is reactivated upon ischemic injury. Differential sprouting programs govern the formation and specification of the venous and arterial coronary plexus.
Keyphrases
- coronary artery disease
- coronary artery
- induced apoptosis
- ultrasound guided
- cell fate
- cell cycle arrest
- single cell
- cell therapy
- public health
- aortic stenosis
- ischemia reperfusion injury
- endoplasmic reticulum stress
- cell death
- oxidative stress
- stem cells
- cell proliferation
- blood brain barrier
- cerebral ischemia
- mesenchymal stem cells
- transcatheter aortic valve replacement
- ejection fraction
- atrial fibrillation