Circulating apoE4 protein levels from dried blood spots predict cognitive function in a large population-based survey setting.
Yacila I Deza-AraujoLuzia M WeissHannah M HortonAijing SunNis Borbye-LorenzenKristin SkogstrandSolveig HolmgaardKaren Andersen-RanbergVania Panes LundmarkAxel Börsch-SupanMartina Börsch-SupanAnna RieckmannPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
An assay to quantify apoE4 levels from dried blood spot samples was applied. The apoE4 protein was detected as specific binding at ≥30,000 pg/mL in 28.4% of samples. Having the apoE4 protein was associated with worse cognitive performance. Higher apoE4 protein levels in those who have it were associated with better cognition. Cardiovascular factors influenced levels of apoE4 protein.