Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.

Lihua ChenXi ChengWenzhi TuZihao QiHaoran LiFei LiuYufei YangZhe ZhangZiliang Wang

Published in: Cellular oncology (Dordrecht) (2019)

From our results, we conclude that apatinib suppresses the in vitro and in vivo viability and proliferation of ovarian cancer cells, as well as glycolysis by inhibiting the VEGFR2/AKT1/GSK3β/SOX5/GLUT4 signaling pathway. Apatinib may serve as a promising drug for the treatment of ovarian cancer.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
transcription factor
stem cells
vascular endothelial growth factor
emergency department
combination therapy
oxidative stress
adverse drug
endoplasmic reticulum stress