Ambient temperature 1 H/ 13 C NMR spectra of sodium 3-(trimethylsilyl)propane-1-sulfonate (DSS) in D 2 O referenced to external TMS: A discussion of these and closely related results. Corrections for the bulk magnetic susceptibility effect for aqueous NMR samples.

This study aimed to obtain the title spectra and verify the temperature dependence of δ DSS of the HOD signal from D 2 O of the NMR sample. However, the analysis of the collected δ X data, extended by the results of other closely related measurements reported in the literature, provided important guidelines for performing routine 1 H/ 13 C NMR spectra in aqueous solvents externally referenced to neat liquid TMS contained in a coaxial capillary. Therefore, it is recommended that the previously proposed correction of δ X data thus determined, which is mainly due to the difference in volume magnetic susceptibility χ v between the sample and the external standard used, usually called the bulk magnetic susceptibility (BMS) correction, has been increased by +0.05 ppm (7%). The new value of this correction, +0.73 ppm, based on NMR experiments carried out at a standard temperature of 25°C, was confirmed in a classical approach using critically reviewed χ m , χ M , and ρ data for TMS, D 2 O, and H 2 O. The BMS correction for H 2 O solutions is +0.75 ppm. Important issues concerning magnetic susceptibility measurements for D 2 O and H 2 O, coaxial bulb-ended inserts, and the geometry of two-tube NMR cells (shape factor α av ) are also critically discussed here, partly from a historical perspective.