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A new perspective on the immune escape mechanism in HCC: onco-foetal reprogramming.

Sin Chi ChewSi Ying ChooPierce Kah-Hoe Chow
Published in: British journal of cancer (2021)
We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages in HCC, mediated via VEGF-NOTCH signalling. The discoveries suggest possible novel targets for therapeutic interventions in HCC.
Keyphrases
  • endothelial cells
  • gestational age
  • vascular endothelial growth factor
  • stem cells
  • physical activity
  • cell proliferation
  • preterm birth