Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD.

Xiuying LiGuillaume NoellTracy TabibAlyssa D GregoryHumberto E Trejo BittarRavi VatsTomasz W KaminskiJohn SembratMark E SnyderDivay ChandraKong ChenChunbin ZouYingze ZhangPrithu SunddJohn F McDyerFrank SciurbaMauricio RojasRobert LafyatisSteve D ShapiroRosa FanerToru Nyunoya

Published in: Respiratory research (2021)

scRNA seq is useful for identifying transcriptional changes and possibly individual protein levels that may contribute to the development of emphysema in a cell-type specific manner.

Keyphrases

single cell
chronic obstructive pulmonary disease
rna seq
lung function
high throughput
genome wide
gene expression
early onset
transcription factor
idiopathic pulmonary fibrosis
air pollution
amino acid
pulmonary fibrosis
dna methylation
oxidative stress
heat stress