Nystagmus may be the first neurological sign in early stages of spinocerebellar ataxia type 3.
Maria Thereza Drumond GamaFlavio Moura Rezende FilhoThiago Junqueira Ribeiro de RezendePedro Braga NetoMarcondes Cavalcante de França JuniorJosé Luiz PedrosoOrlando Grazianni Povoas BarsottiniPublished in: Arquivos de neuro-psiquiatria (2021)
Our study showed that nystagmus may be the first neurological sign in SCA3. This clinical observation reinforces the idea that the neurodegenerative process in SCA3 patients may start in vestibular system connections or in flocculonodular lobe. This study adds relevant information about pre-symptomatic features in SCA3 that may work as basis for a better understanding of brain degeneration and for future therapeutic clinical trials.