Hyperosmolar Ionic Solutions Modulate Inflammatory Phenotype and sGAG Loss in a Cartilage Explant Model.

Ahmad S ArabiyatHongyu ChenJoshua D Erndt-MarinoKatie BurkhardLisa ScolaAllison FleckLeo Q WanMariah S Hahn

Published in: Cartilage (2020)

These results suggest that these ionic species elicit varying responses in TNF-α-stimulated explants. Cumulatively, these findings support additional studies of hyperosmolar ionic solutions for potential development of novel intraarticular injections targeting OA.

Keyphrases

ionic liquid
solid state
rheumatoid arthritis
oxidative stress
knee osteoarthritis
cancer therapy
case control
risk assessment
drug delivery
climate change