Tract-wise microstructural analysis informs on current and future disability in early multiple sclerosis.
Veronica RavanoGian Franco PireddaJan KrasenskyMichaela AndelovaTomas UherBarbora SrpovaEva Kubala HavrdováKarolina VodehnalovaDana HorákováPetra NytrovaJonathan A DisselhorstTom HilbertBénédicte MaréchalJean Philippe ThiranTobias KoberJonas RichiardiManuela VaněčkováPublished in: Journal of neurology (2023)
We showed that microstructural changes evaluated in specific WM pathways contribute to explaining future disability in early MS, hence highlighting the potential of tract-wise analyses in monitoring disease progression. Further, the proposed technique allows to estimate WM tract-specific microstructural characteristics in clinically compatible acquisition times, without the need for advanced diffusion imaging.