Impact of PPAR-gamma activation on the durability of biological heart valve prostheses in hypercholesterolaemic rats.
Anna Kathrin AssmannVanessa WinnickiYukiharu SugimuraAgunda ChekhoevaMareike BarthAnna Kathrin AssmannArtur LichtenbergPayam AkhyariPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2023)
Systemic peroxisome proliferator-activated receptor gamma activation decreases intima hyperplasia and subsequent intima calcification of cryopreserved allografts in obese, hypercholesterolaemic recipients. Additionally, it seems to inhibit functional impairment of the implanted aortic valve. Further preclinical studies are required to determine the long-term impact of peroxisome proliferator-activated receptor gamma agonists on graft durability.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- aortic stenosis
- transcatheter aortic valve implantation
- aortic valve replacement
- cardiovascular risk factors
- adipose tissue
- heart failure
- metabolic syndrome
- chronic kidney disease
- insulin resistance
- weight loss
- atrial fibrillation
- mitral valve
- cell therapy
- stem cells
- cardiovascular disease
- obese patients
- ejection fraction
- bariatric surgery
- cord blood
- coronary artery disease
- case control
- skeletal muscle