Population total and unbound pharmacokinetics and pharmacodynamics of ciprofol and M4 in subjects with various renal functions.

Shuai-Bing LiuXia YaoJun TaoJian-Jun YangYing-Ying ZhaoDong-Wei LiuSu-Yun WangSu-Ke SunXu WangPang-Ke YanNan WuXiao LiuXiao-Jian ZhangXin TianZhang-Suo Liu

Published in: British journal of clinical pharmacology (2022)

The developed model fully characterized the population PK and PD profiles of ciprofol. No dose adjustment is required in patients with mild and moderate renal impairment.

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