Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies.
Yuting MaHeng YangGuido KroemerPublished in: Oncoimmunology (2019)
Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dendritic cells, causing the subversion of cancer therapy-elicited antineoplastic immune responses and subsequent therapeutic failure.
Keyphrases
- dendritic cells
- immune response
- anti inflammatory
- cancer therapy
- transcription factor
- papillary thyroid
- drug delivery
- mental health
- squamous cell
- regulatory t cells
- toll like receptor
- squamous cell carcinoma
- stress induced
- lymph node metastasis
- combination therapy
- heat stress
- drug induced
- young adults
- genome wide identification