Acute hyperbilirubinemia determines an early subclinical renal damage: Evaluation of tubular biomarkers in cholemic nephropathy.
Sabrina ScillettaStefano LeggioMaurizio Di MarcoNicoletta MianoMarco MusmeciNicola MarranoAnnalisa NatalicchioFrancesco GiorginoGiosiana BoscoFrancesco Di Giacomo BarbagalloAlessandra ScamporrinoStefania Di MauroAgnese FilippelloRoberto ScicaliMaurizio RusselloLuisa SpadaroFrancesco PurrelloSalvatore PiroAntonino Di PinoPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
This study demonstrated increased urinary biomarkers of tubular damage (u-NGAL, u-B2M, u-OPN, u-TFF3, and u-Cys) in patients with mild hyperbilirubinemia in comparison with a control group. These findings suggest early renal tubular damage in the absence of alterations of the normal parameters used in clinical practice (eGFR, serum urea and renal morphology).