High prevalence and mortality due to Histoplasma capsulatum in the Brazilian Amazon: An autopsy study.
Natalia RakislovaJuan Carlos HurtadoAntonio E M PalharesLuiz Carlos de Lima FerreiraMonique Freire SantanaMarcus Vinícius Guimarães de LacerdaWuelton MonteiroMireia NavarroIsaac CasasMarcus de Melo TeixeiraPaola CastilloMaria Teresa Rodrigo-CalvoLorena MarimonJosé GuerreroRosauro VaroVima DelgadoLlorenç QuintòFrancesc MarcoEmilio LetangJordi VilaSozinho AcácioClara MenéndezJaume OrdiMiguel Julián Martínez YoldiPublished in: PLoS neglected tropical diseases (2021)
The high incidence of histoplasmosis, the low index of clinical suspicion, and the severity of the disseminated disease highlight the need of proactively implementing sensitive routine screening methods for this pathogen in endemic areas. Antifungal prophylaxis against Histoplasma should be encouraged in the severely immunocompromised HIV patients in these areas. In conclusion, substantial mortality is associated with disseminated histoplasmosis among HIV-positive patients in the Brazilian Amazon.
Keyphrases
- hiv positive
- end stage renal disease
- risk factors
- antiretroviral therapy
- newly diagnosed
- ejection fraction
- chronic kidney disease
- men who have sex with men
- peritoneal dialysis
- human immunodeficiency virus
- hiv infected
- cardiovascular events
- prognostic factors
- hiv aids
- intensive care unit
- coronary artery disease
- hiv testing
- acute respiratory distress syndrome
- patient reported