Developmental population pharmacokinetics of caffeine in Chinese premature infants with apnoea of prematurity: A post-marketing study to support paediatric labelling in China.

Xiang-Bo GaoYi ZhengFan YangChen-Hong WangZhou-Hong JiangYue-E WuÉvelyne M Jacqz-AigrainShao-Qing NiWei Zhao

Published in: British journal of clinical pharmacology (2020)

A population PK model of caffeine was developed in Chinese newborns. Body weight-implemented allometric scaling, postmenstrual age and serum creatinine concentration markedly affected caffeine clearance. The labelled dosing regimen is suitable for Chinese premature infants.

Keyphrases

body weight
low birth weight
intensive care unit
emergency department
pregnant women
preterm infants
metabolic syndrome
positive airway pressure
preterm birth