Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy.

Marco Luciani Montalbano Mauro Luca Troncone Camilla Bacchin Keita Uchida Gianlorenzo Daniele Bethany J Wolf Helen M ButlerJustin KielStefano Berto Cortney Gensemer Kelsey S Moore Jordan E Morningstar Thamonwan Diteepeng Onder Albayram Jose Francisco Abisambra Russell A Norris Thomas G Di Salvo Benjamin L Prosser Rakez Kayed Federica Del Monte

Published in: European heart journal (2023)

The study presents new mechanistic evidence and potential treatment for the brain-heart tauopathy axis in myocardial and brain degenerative diseases and ageing.

Keyphrases

left ventricular
resting state
white matter
small molecule
heart failure
blood pressure
functional connectivity
cerebral ischemia
big data
high throughput
cerebrospinal fluid
risk assessment
brain injury
multiple sclerosis
subarachnoid hemorrhage
human health