Longitudinal Changes of Serum Creatine Kinase and Acute Kidney Injury among Patients with Severe COVID-19.
Juan M Soto-FajardoValeria J Castillo-AvalosElisa Naomi Hernandez-ParedesAiry Santillán-CerónJorge E Gaytan-ArochaOlynka Vega-VegaNorma Ofelia Uribe-UribeRicardo Correa-RotterJuan Carlos Ramírez-SandovalPublished in: International journal of nephrology (2022)
In severe COVID-19 patients, a slight increase in creatine-kinase levels was observed after AKI occurrence but not before. Our results show that, at least for the appearance of hospital-acquired AKI, the CK rise does not meet the temporality criterion of causality regarding the occurrence of AKI. Rising creatine-kinase trends were associated with a higher risk of mortality, but this association was modified by AKI evolution and inflammation. There is a limited efficiency for AKI prognosis in the serial follow-up of CK levels in severe COVID-19 patients with normal renal function.