Opioid versus non-opioid analgesia for spine surgery: a systematic review and meta-analysis of randomized controlled trials.
Kamath SriganeshSuparna BharadwajHarsha ShanthannaGanne S Umamaheswara RaoBoris W KramerTalakad N SathyaprabhaPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2022)
The certainty of evidence on GRADE assessment is low for studied outcomes. Available evidence supports intraoperative non-opioid analgesia for overall postoperative pain outcomes in spine surgery. More research is needed to find the best drug combination and dosing regimen. Prospero Registration: CRD42020209042.