An enhancer demethylator phenotype converged to immune dysfunction and resistance to immune checkpoint inhibitors in clear-cell renal cell carcinomas.

Xiaofan Lu Yann-Alexandre Vano Alexandra Helleux Xiaoping Su Veronique Lindner Guillaume Davidson Roger Mouawad Jean-Philippe Spano Morgan Roupret Reza-Thierry Elaidi Eva M Comperat Virginie Verkarre Cheng-Ming Sun Christine Chevreau Mostefa Bennamoun Hervé Lang Thibault Tricard Wenxuan Cheng Li Xu Irwin Davidson Fangrong Yan Wolf Herman Fridman Catherine Sautès-Fridman Stephane Marie Oudard Gabriel G Malouf

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

We report on the discovery of a novel epigenetic phenotype associated with resistance to immune checkpoint inhibitors that may pave the way to better personalizing patients' treatments.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
clear cell
chronic kidney disease
gene expression
small molecule
single cell
prognostic factors
peritoneal dialysis
oxidative stress
high grade
high throughput
cell therapy
binding protein
patient reported