PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS.

Maysaa AbdullaAndrei AlexssonChrister SundströmClaes LadenvallLarry MansouriCecilia LindskogMattias BerglundLucia CavelierGunilla EnbladPeter HollanderRose-Marie Amini

Published in: Acta oncologica (Stockholm, Sweden) (2021)

Our study shows a significant association between gene and protein expression of IDO1 and protein expression of PD-L1 in the tumor microenvironment of PCNSL, possibly of importance for prediction of response to immunotherapies.

Keyphrases

diffuse large b cell lymphoma
epstein barr virus
blood brain barrier
genome wide
copy number
gene expression
risk assessment
human health