Blood direct PCR: impact of CYP2C19 and CYP4F2 variants for bleeding prediction in ST-elevation myocardial infarction patients with ticagrelor.
Vacis TatarunasAli AldujeliZemyna KurnickaiteLaurynas MaciuleviciusMarius BurkanasJonas VeniusIeva CiapieneVilius SkipskisRita NorvilaiteAgne GiedraitieneRamunas UnikasGiedre BaksyteOlivija GustieneGintare SakalyteVaiva LesauskaitėPublished in: Personalized medicine (2022)
Aims: The goals of this study were to develop a new technique that could pave the way for a quicker determination of CYP4F2 rs3093135 and CYP2C19 rs4244285 variants directly from a patient's blood and to attempt to apply this technique in clinical practice. Patients & methods: The study included 144 consecutive patients admitted with ST elevation myocardial infarction. A blood-direct PCR and real-time PCR were used to detect variants of interest. Results & conclusion: Patients with bleeding events had the CYP2C19 GG (*1*1) variant more frequently than patients without bleeding events. The CYP4F2 TT variant was more frequently detected in patients with bleeding events 3 months after hospitalization.
Keyphrases
- st elevation myocardial infarction
- percutaneous coronary intervention
- end stage renal disease
- atrial fibrillation
- newly diagnosed
- ejection fraction
- real time pcr
- chronic kidney disease
- copy number
- clinical practice
- peritoneal dialysis
- acute coronary syndrome
- coronary artery disease
- gene expression
- patient reported outcomes
- genome wide