Catechol-O-methyltransferase Val158Met polymorphism is associated with increased risk of multiple uterine leiomyomas either positive or negative for MED12 exon 2 mutations.
Lyailya Kh DzhemlikhanovaOlga A EfimovaNatalia S OsinovskayaSergey E ParfenyevDariko A NiauriIskender Yu SultanovOlga V MalyshevaAnna A PendinaNatalia Yu ShvedTatyana E IvashchenkoMaria I YarmolinskayaMaka I KakhianiEkaterina A GorovayaAntonina N TkachenkoVladislav S BaranovPublished in: Journal of clinical pathology (2016)
Women with COMT Val/Val genotype are at high risk of developing multiple uterine fibroids either positive or negative for MED12 exon 2 mutations. These data are important to design new strategies for UL prophylaxis and treatment.