Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes.
Tang Cam Phung PhamKirstine Nyvold Bojsen-MøllerSten MadsbadJørgen Frank Pind WojtaszewskiErik Arne RichterLykke SylowPublished in: International journal of obesity (2005) (2020)
In subjects with preoperative T2D, RYGB did not increase circulating Fst contrasting subjects with NGT, while the reduction in activin A was maintained. ActRIIB signaling was upregulated in adipose tissue, but not skeletal muscle, following RYGB in both individuals with NGT and T2D. Our results suggest a role of adipose tissue ActRIIB signaling for the beneficial effects of RYGB surgery.
Keyphrases
- roux en y gastric bypass
- weight loss
- adipose tissue
- insulin resistance
- gastric bypass
- type diabetes
- skeletal muscle
- obese patients
- bariatric surgery
- high fat diet
- metabolic syndrome
- cardiovascular disease
- weight gain
- high fat diet induced
- coronary artery bypass
- coronary artery disease
- body mass index
- percutaneous coronary intervention