Alteration of liver-infiltrated and peripheral blood double-negative T-cells in primary biliary cholangitis.
Shu X LiTing T LvChun P ZhangTian Q WangDan TianGuang Y SunYan WangXin-Yan ZhaoWei J DuanSha ChenMin LiHong MaYuan Y KongHong YouXiao J OuGuang Y ChenJian R SuDong ZhangJi D JiaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
Decreased quantity and function of DN T-cells in PBC may result in the loss of immune regulations on effector CD4+ and cytotoxic CD8+ T-cells, and thereby may break the immune tolerance and promote the pathogenesis of PBC.