Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis.

Ming WangDan-Qian ChenLin ChenGang CaoHui ZhaoDan LiuNosratola D VaziriYan GuoYing-Yong Zhao

Published in: British journal of pharmacology (2018)

The secolanostane tetracyclic triterpenoids effectively blocked RAS by simultaneously targeting multiple RAS components and lanostane tetracyclic triterpenoids inhibited renin and protected against tubulo-interstitial fibrosis.

Keyphrases

wild type
stem cells
epithelial mesenchymal transition
cell proliferation
transforming growth factor
liver fibrosis
cancer therapy
protein kinase
angiotensin converting enzyme
signaling pathway