RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.

Abhishek Singh SengarManish KumarChetna RaiSreemoyee ChakrabortiDinesh KumarPranesh KumarSukhes MukherjeeKausik MondalAdele StewartBiswanath Maity

Published in: Journal of translational medicine (2024)

Together, these data implicate RGS6 as a driver of nucleolar stress-dependent cell death in cardiomyocytes via its ability to modulate Nucleolin. This work represents the first demonstration of a functional role for an RGS protein in the nucleolus and identifies the RGS6/Nucleolin interaction as a possible new therapeutic target in the prevention of cardiotoxicity.

Keyphrases

cell death
genome wide
stress induced
angiotensin ii
high glucose
gene expression
binding protein
heat stress
signaling pathway
small molecule
cell cycle arrest
pi k akt