Differential modulation of human GABAC-ρ1 receptor by sulfur-containing compounds structurally related to taurine.
Lenin David Ochoa-de la PazMartin González-AndradeHerminia Pasantes-MoralesRodrigo FrancoRubén Zamora-AlvaradoEdgar ZentenoHugo Quiroz-MercadoRoberto Gonzales-SalinasRosario Gulias-CañizoPublished in: BMC neuroscience (2018)
The sulfur-containing compounds structurally related to taurine are partial agonists of GABAC-ρ1R that occupy the agonist binding site. The dual effect is unique to taurine, whereas in the case of hypotaurine and homotaurine it presents separately; hypotaurine increases and homotaurine decreases the GABA current.
Keyphrases