Tissue 2-Hydroxyglutarate and Preoperative Seizures in Patients With Diffuse Gliomas.

Makoto OhnoYoshiharu HayashiHiroaki AikawaMitsuhiro HayashiYasuji MiyakitaMasamichi TakahashiYuko MatsushitaAkihiko YoshidaKaishi SatomiKoichi IchimuraAkinobu HamadaYoshitaka Narita

Published in: Neurology (2021)

We showed that high tissue 2HG concentration was associated with preoperative seizures, suggesting that excess 2HG increases risk of preoperative seizures in IDH1/2 mutant tumors.

Keyphrases

patients undergoing
low grade
high grade
fluorescent probe
wild type
aqueous solution
single molecule