Immunohistochemical Characterization of Immune Infiltrate in Tumor Microenvironment of Glioblastoma.

Hassan Rahimi Koshkaki Simone Minasi Alessio Ugolini Gianluca Trevisi Chiara NapoletanoIlaria G ZizzariMarco GessiFelice GiangasperoAnnunziato MangiolaMarianna Nuti Francesca Romana ButtarelliAurelia Rughetti

Published in: Journal of personalized medicine (2020)

Distinct inhibitory mechanisms can act simultaneously in both the TC and PTA to contribute to the strong immunosuppression observed within the GBM microenvironment. Nevertheless, the PTA shows strongly reduced immunosuppression when compared to the TC, thus representing a potential target for immunotherapies. Moreover, our results support the working hypothesis that immunosuppression and T-cell exhaustion can be simultaneously targeted to rescue anti-tumor immunity in GBM patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
stem cells
risk assessment
patient reported