O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis.

Xun WangZhihui FengXueqiang WangLiang YangShujun HanKe CaoJie XuLin ZhaoYong ZhangJiankang Liu

Published in: Diabetologia (2016)

These data suggest that OGA can modulate mitochondrial density via PGC-1α and mitochondrial function via protein O-GlcNAcylation. In this manner, OGA appears to play a key role in myogenesis and the development of muscle insulin resistance.

Keyphrases

insulin resistance
skeletal muscle
high fat diet induced
oxidative stress
adipose tissue
type diabetes
electronic health record
signaling pathway
metabolic syndrome
high fat diet
big data
protein protein
amino acid
binding protein
machine learning
small molecule
deep learning
artificial intelligence