Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages.
Felix RenaudinLucie OrliaguetFlorence CastelliFrançois FenailleAurelie PrignonFawaz AlzaidChristele CombesAurélie DelvauxYasmina AdimyMartine Cohen SolalPascal RichetteThomas BardinJean-Pierre RivelineNicolas VenteclefFrédéric LiotéLaure Campillo-GimenezHang-Korng EaPublished in: Annals of the rheumatic diseases (2020)
In conclusion, we demonstrated that GLUT1-mediated glucose uptake is instrumental during the inflammatory IL-1β response induced by MSU and CPP crystals. These findings open new therapeutic paths to modulate crystal-related inflammation.