A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways.
Anne Sophie HamyHélène Bonsang-KitzisMarick LaeMatahi MoariiBenjamin SadaccaAlice PinheiroMarion GalliotJudith AbecassisCecile LaurentFabien ReyalPublished in: PloS one (2016)
The identification of a predictive and prognostic immune module in HER2-positive BC confirms the need for clinical testing for immune checkpoint modulators and vaccines for this specific subtype. The inverse correlation between Immunity and hormone pathways opens research perspectives and deserves further investigation.