Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes.

Yvonne de JongMartha IngolaInge H Briaire-de BruijnAlwine B KruisselbrinkSanne VennekerIeva PalubeckaiteBram P A M HeijsAnne-Marie Cleton-JansenRick L M HaasJudith V M G Bovée

Published in: Clinical sarcoma research (2019)

Chondrosarcoma cell lines as well as primary tumors are variably radioresistant, particularly in case of a defective Rb pathway. Whether selection for radiotherapy can be based upon an intact Rb pathway should be further investigated.

Keyphrases

cell cycle
early stage
cell proliferation
locally advanced
induced apoptosis
radiation therapy
radiation induced
cell cycle arrest
atomic force microscopy
mass spectrometry
pi k akt
high resolution
high speed