PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma.
Prakrit R KumarMona SaadCharlotte HellmichJayna J MistryJamie A MooreShannon ConwayChristopher J MorrisKristian M BowlesMarc D S MoncrieffStuart A RushworthPublished in: British journal of cancer (2022)
MSC mitochondrial biogenesis stimulated by melanoma cells is prerequisite for mitochondrial transfer and subsequent tumour growth, where targeting this pathway may provide an effective novel therapeutic approach in melanoma.