Novel polyketide from Fusarium verticillioide G102 as NPC1L1 inhibitors.

One novel polyketide, fusaritide A ( 1 ), was isolated from a marine fish-derived halotolerant fungal strain Fusarium verticillioide G102. The structure was determined through extensive spectroscopic analysis and high-resolution electrospray ionization mass spectrometry. Fusaritide A ( 1 ) with unprecedented structure reduced cholesterol uptake by inhibiting Niemann-Pick C1-Like 1 (NPC1L1).