High histamine levels are associated with acute-on-chronic liver failure and liver-related death in patients with advanced chronic liver disease.
Michael SchwarzBenedikt SimbrunnerMathias JachsLukas HartlLorenz BalcarDavid Josef Maria BauerGeorg SemmlerBenedikt Silvester HoferBernhard ScheinerMatthias PinterAlbert Friedrich StättermayerMichael TraunerThomas ReibergerMattias MandorferPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
High levels of histamine were linked to circulatory dysfunction in ACLD patients and independently associated with increased risks of ACLF or liver-related death. Further mechanistic studies on the link between histamine signalling and development of hyperdynamic circulation and ACLF are warranted.