High histamine levels are associated with acute-on-chronic liver failure and liver-related death in patients with advanced chronic liver disease.

Michael Schwarz Benedikt Simbrunner Mathias Jachs Lukas Hartl Lorenz Balcar David Josef Maria Bauer Georg Semmler Benedikt Silvester Hofer Bernhard Scheiner Matthias Pinter Albert Friedrich Stättermayer Michael Trauner Thomas Reiberger Mattias Mandorfer

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

High levels of histamine were linked to circulatory dysfunction in ACLD patients and independently associated with increased risks of ACLF or liver-related death. Further mechanistic studies on the link between histamine signalling and development of hyperdynamic circulation and ACLF are warranted.

Keyphrases

liver failure
hepatitis b virus
end stage renal disease
drug induced
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
oxidative stress
peritoneal dialysis
extracorporeal membrane oxygenation
climate change