Differential maturation trajectories of innate antiviral immunity in health and atopy.
Anastasia GeorgountzouDimitra KokkinouStella TakaParaskevi MagginaJohn LakoumentasVassiliki PapaevangelouMaria TsoliaParaskevi XepapadakiEvangelos AndreakosNikolaos G PapadopoulosPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)
TLR3 and TLR7/8 pathways mature during childhood, while atopy is associated with an abnormal maturation pattern. Suboptimal responses in Th1, inflammatory cytokine, and chemokine production may be implicated in poor antiviral immunity in atopics. Moreover, the deficient maturation of IL-10 synthesis may be implicated in the breaking of tolerance, characterizing the onset of atopic disease.