Measurement of anti SARS-CoV-2 RBD IgG in saliva: validation of a highly sensitive assay and effects of the sampling collection method and correction by protein.

Silvia Martinez-SubielaLorena Franco-MartínezCamila Peres RubioAlberto Muñoz-PrietoAlberto Torres-CanteroFernando TeclesCristina Sánchez-ResaltJosé J CerónAsta Tvarijonaviciute

Published in: Clinical chemistry and laboratory medicine (2022)

The developed method showed a good analytical performance and can properly measure antibody concentrations in saliva of vaccinated individuals. However, saliva could have a lower sensitivity compared to serum at initial stages of the immune response and also when the antibody response decreased after a stimulus.

Keyphrases

sars cov
immune response
high throughput
respiratory syndrome coronavirus
dendritic cells
fluorescent probe
high resolution
coronavirus disease