Somatic variants of potential clinical significance in the tumors of BRCA phenocopies.

Lela E BuckinghamRachel MitchellMark Maienschein-ClineStefan GreenVincent Hong HuMelody CobleighJacob RotmenschKelly BurgessLydia Usha

Published in: Hereditary cancer in clinical practice (2019)

Although limited by a small sample size, these results support a role of selected somatic variants and epigenetic mechanisms in the development of tumors in BRCA phenocopies.

Keyphrases

copy number
dna methylation
genome wide
gene expression
breast cancer risk
risk assessment
human health