A Pt nanoenzyme- and BODIPY-loaded nanoscale covalent organic framework for relieving intratumoural hypoxia to enhance photodynamic therapy.
Kai-Xuan ZhangBo WangWen-Yan LiYang SongTian SongYan-An LiYu-Bin DongPublished in: Dalton transactions (Cambridge, England : 2003) (2024)
Herein, we report a composite COF material loaded with a Pt nanoenzyme and an organic photosensitizer BODIPY, synthesized via a stepwise post-synthetic modification. The obtained Pt@COF-BDP nanoparticles can efficiently and continuously convert H 2 O 2 to O 2 , thereby increasing the efficiency of single-linear oxygen production and achieving efficient tumor inhibition.