Triphenylamine Sensitized 8-Dimethylaminoquinoline: An Efficient Two-Photon Caging Group for Intracellular Delivery.

Delphine RigaultPhilippe NizardJonathan DanielMireille Blanćhard-DesceEric DeprezPatrick TaucHamid DhimanePeter I Dalko

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2024)

Triphenylamine-sensitized 8-dimethylaminoquinoline (TAQ) probes showed fair two-photon absorption and fragmentation cross sections in releasing kainate and GABA ligands. The water-soluble PEG and TEG-analogs allowed cell internalization and efficient light-gated liberation of the rhodamine reporter under UV and two-photon (NIR) irradiation conditions.

Keyphrases

living cells
fluorescent probe
water soluble
fluorescence imaging
single cell
monte carlo
single molecule
cell therapy
small molecule
crispr cas
drug delivery
photodynamic therapy
reactive oxygen species
molecular docking
stem cells
drug release
radiation therapy