Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse.
Željko AntićJiangyan YuBeat C BornhauserStefan H LelieveldCedric G van der HamSimon V van ReijmersdalLionel MorgadoSarah ElitzurJean-Pierre BourquinGiovanni CazzanigaCornelia EckertMireia CamósRosemary SuttonHélène CavéAnthony V MoormanEdwin SonneveldAd Geurts van KesselFrank N van LeeuwenPeter M HoogerbruggeEsmé WaandersRoland P KuiperPublished in: Pediatric blood & cancer (2021)
Comprehensive genomic characterization of diagnosis-relapse pairs shows that very early relapses in BCP-ALL frequently arise from minor subclones at diagnosis. A detailed understanding of the therapeutic pressure driving these events may aid the development of improved therapies.