Highly inert Cu(II) complexes of C -aryl bifunctional cyclam-picolinates with remarkable 64 Cu-labelling and biodistribution.
Julie PineauLuís M P LimaMarie M Le RoySéverine Marionneau-LambotMarie CordierPatricia Le SaëcJan Rijn ZeevaartCathryn H S DriverAlain Faivre-ChauvetNathalie Le BrisPr Raphael TripierPublished in: Chemical communications (Cambridge, England) (2023)
Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64 Cu-radiocomplexes. The C -aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.