Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury.

Niketa A PatelLauren Daly MossJea-Young LeeNaoki TajiriSandra AcostaCharles HudsonSajan ParagDenise R CooperCesario V BorlonganPaula C Bickford

Published in: Journal of neuroinflammation (2018)

We demonstrate that MALAT1 in hASC-derived exosomes modulates multiple therapeutic targets, including inflammation, and has tremendous therapeutic potential for treatment of TBI.

Keyphrases

traumatic brain injury
long noncoding rna
mesenchymal stem cells
stem cells
oxidative stress
severe traumatic brain injury
cell therapy
smoking cessation