From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis.

Aernoud A van BatenburgKarin M KazemierMatthijs F M van OosterhoutJoanne J van der VisHendrik W van EsJan C GruttersRoel GoldschmedingColine H M van Moorsel

Published in: PloS one (2020)

Average lung tissue telomere shortening does not associated with fibrotic patterns in IPF, however, approximately half of IPF patients show excessive lung telomere shortening that is associated with pulmonary fibrosis driven by telomere attrition.

Keyphrases

idiopathic pulmonary fibrosis
pulmonary fibrosis
interstitial lung disease
end stage renal disease
ejection fraction
newly diagnosed
single cell
prognostic factors
patient reported outcomes
bone marrow
physical activity
weight gain
clinical evaluation